New Autism Treatment Drug, KM-391 is in Development
The Autism News | English
By KC Kelly Ph.D. | Huliq
Breaking news was released today regarding the Cellceutix Corporation, a preclinical cancer, autism and anti-inflammatory drug developer, and its new rights to pursue the development of the drug KM-391, for the treatment of autism spectrum disorder. The drug is said to work on the “Neonatal serotonin depletion and reduced plasticity of the brain which are salient features observed in Autism,” according to Cellceutix.
George Evans, the CEO of Cellceutix talked about the company’s new compound KM-391 in attempt to get shareholders of the company excited about the new development. The compound, KM-391 was acquired by Cellceutix in December, 2009 and in January 2010, an article was published by Business Week about the “drug industry is finally gearing up for an assault on autism.”
Mr. Evans stated, “Autism is a condition where there is loss in certain brain functions, which leads to behavior disorder. The present scientific research directs us to a few things. One being the plasticity of brain tissue, the second being nerve tangling in the brain and the third being uneven production of serotonin, all which may have a significant effect on evolution and degree of severity of autism in any particular individual.”
Since there are currently no drugs on the market that are approved to treat symptoms of autism, Cellceutix is working as rapidly as possible to learn more about the potential for the development of KM-391 and is very encouraged about it thus far. The drug was first developed as a small molecule in India and now is being “synthesized in the United States for continued research”.
There is very promising data on the drug KM-391. Although KM-391 has not been studied in humans at this time, it has already showed positive results in animal studies. Cellceutix stated, “Preliminary testing of KM 391 in mice revealed that the test animals showed a significant increase in serotonin uptake compared to controls, with no apparent side-effects in the long-term administration of KM 391 in mice.”
The FDA has yet to approve any drugs for autism and Cellceutix is hoping to be the first company that becomes approved with a successful drug which the face of autism spectrum disorder forever. That drug is KM-391.
Mr. Evans stated, “We are extremely excited about the data on KM-391 and the potential for the compound in this area of urgent medical need. Diagnoses of autism are rising dramatically and the disease takes a terrible toll on families. There is a critical need for new treatments for autism and we are pleased to be part of the effort to find them.”
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For a 10-year-old, baseball inspiration
The Autism News | English
Charles Karstedt instructs Alex Ward, 10, on batting technique at Nickel City Baseball’s first skills and conditioning clinic for children with high-functioning autism.
By Jackie Smith | The Buffalo News – City & Region
Tracey Ward cheered and applauded as she watched her son Alex run the bases Tuesday at New Era Park in Hamburg.
The 10-year-old Alden resident had just connected with the ball during a one-hour baseball skills and conditioning clinic at the indoor facility on Lake Avenue.
The occasion was Nickel City Baseball’s first-ever clinic for children with high-functioning autism, or Asperger syndrome. Alex, who is autistic, was the first official player-in-training.
“All the way home, Alex!” instructor Charles Karstedt urged as the boy rounded third base. “That really was a home run. That was your farthest one yet.”
It is not very often that Alex engages in those types of activities. Ward said her son, at times, is anxious about playing sports, but she hopes the clinic will help turn that around, improve his social and motor skills, and give him a reason for enthusiasm.
“Sometimes it’s hard to motivate Alex to do things,” Ward said. “Sometimes it takes a program where people have a little niche or trick to get him to do things. Last year, we had him in a camp to learn to ride a bike, and he did it in two days, so I was hoping this would be along the same lines.”
Nickel City co-founder Sean Lewis said that was the intention — to help children with special needs gain confidence and improve their hand-eye coordination. The idea for the clinic, he said, was from the mother of four autistic children, who worked with his partner, Justin Santonocito.
“They have brothers and sisters playing in Little Leagues and things like that, which [specialneeds] children also want to participate in,” Lewis said. “But there was not so much a great vast of opportunities for children with autism to do athletic activities.”
Lewis said the clinic puts children through short drills followed by a period when they can decompress and rest. Though Alex was the first and only participant Tuesday, Lewis said, he expects up to 30 children a session.
The program will be offered at 4:30 p. m. each Tuesday through Aug. 24. If it is successful, Lewis said, it could be expanded.
Karstedt said he has worked with other children before. At times, children can “be off the walls” when learning baseball skills, he said, but Alex was very perceptive.
“You just tell him to focus on a couple things,” Karstedt said. “A kid like Alex is great to work with. He gets everything.”
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W.Va. Attorney General’s Office Files Lawsuit in Fundraising Scam
The Autism News | English
By WTRF 7
Three people are accused of falsely representing that a charity would benefit children with autism.
CHARLESTON — The Attorney General’s Office Consumer Protection Division filed a lawsuit July 7 against two Kentucky residents and an Ohio woman for allegedly trying to violate the state’s consumer protection laws.
According to a news release from Attorney General Darrell McGraw’s office, the lawsuit names William S. Terry and Herbert L. Terry, both of Sandy Hook, Ky., and Vicky Perdue of Proctorville, Ohio. It accuses the three people of allegedly starting a charitable organization called Mikayla’s Place that they said was affiliated with Autism Speaks, a Delaware charitable organization.
According to the news release, the three people told consumers that they were selling computers and other electronic equipment to raise money for a camp for children with autism and other special needs. The three people said the computers had been donated by corporate sponsors and some federal and state agencies.
The news release said that wasn’t true. The Attorney General’s Office alleges the three people purchased the computers at liquidation sales and surplus auctions. In addition, McGraw’s office said neither the Terrys and Perdue nor Mikayla’s Place were registered with the West Virginia Secretary of State’s Office to solicit funds for a charity.
In the news release, McGraw stated his office became aware of the scam when consumers began filing complaints with his Consumer Protection Division. He said consumers complained that they had ordered laptop computers from the defendants because they were told the money was for a fundraiser for Mikayla’s Place and Autism Speaks. The consumers were charged $50.00 for each computer they ordered and were promised delivery within a certain period of time. Most consumers never received a computer. Many never received a refund.
“Consumers must be wary of anyone who contacts them raising funds for any charitable organization,” McGraw said in the release. “The law requires all charitable organizations and the people who solicit donations for them to register with the Secretary of State. Consumers should always contact the Secretary of State’s office to ensure the organization is, in fact, a charity.”
West Virginia consumers who purchased merchandise in connection with fund-raising for Mikayla’s Place can file a complaint with the Attorney General’s Consumer Protection Division by calling the Consumer Protection Hotline, 1-800-368-8808, or by obtaining a complaint form at www.wvago.gov.
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N.J. parents of autistic children need more state support, resources, report says
The Autism News | English
Kim Cristo, right, looks on as her 2-year-old daughter, Ava, receives occupational therapy from Michelle Doonan, an applied behavioral analysts. Ava was diagnosed early on with autism and receives two hours of therapy at her home.
By Susan K. Livio | NJ
An in-depth survey of parents raising a child with autism found families need the state to take a more active role in helping them find the right therapists, schools, job training and respite care services.
And they want Autism New Jersey, the family support organization that conducted the survey, to become a greater force at the Statehouse to fight their cause.
Autism New Jersey is expected to distribute the report Thursday to the Legislature, members of Gov. Chris Christie’s cabinet, and local elected leaders.
“In order to make meaningful change, they told us to change Trenton,’’ said Autism New Jersey Executive Director Linda Meyer.
Parents in New Jersey — where the autism rate is highest in the nation — are often too consumed with looking for therapy or educational or vocational programs for their child to solve the red tape of government-funded services, Meyer said. “So often, families are very negative and frustrated and challenged by the system,” she said.
“Rather than add to the chorus of much deserved criticism, Autism New Jersey chose instead to listen to not only the needs but the hopes and dreams of the autism community,” according to the 25-page report.
The group conducted 2,000 hours of interviews with 537 people, nearly 70 percent parents or grandparents and the rest teachers, doctors or other professionals. Every county was represented; nearly half the participants live in Bergen, Mercer and Middlesex.
Nearly 400 people expressed their desire to see the quality of professionals who work in the autism field improve. They need to not only be experienced and well-trained, but also “respectful of the individual with autism and the family,” “loving,” “engaging,” “unflappable,” and “positive.”
Meyer said she knows the wish list lands at time of unprecedented budget-tightening. To pitch-in, Autism New Jersey will compile a directory of employers and nonprofits willing to provide volunteer and paying jobs for people with autism, and relaunch its website “to lead people to what we hope will be true sources of information,” Meyer said.
State Human Services Commissioner Jennifer Velez, who viewed a copy of the report, said its “valuable personal perspectives of families’’ will help guide the department as it plans to create an Office on Autism.
Kim Cristo with her 2-year-old daughter, Ava, who was diagnosed early on with autism. She now receives therapy at her home in North Haledon.
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Living With Autism: Miracles Have Wings
The Autism News | English
By Elaine Hall | Huffington Post
How do you know if you are doing the right therapy for your child? With so many “remedies,” “cures” and paths to take, how do you know if you are on the “right” one? How do we know if it’s “working?”
Like most things in my life, my answers didn’t evolve gradually; they hit me over the head. There’s a story about a man so eager to “help” a butterfly into the world that he opens its chrysalis too soon. The result is tragic: the wings never develop properly, the butterfly cannot fly, and it dies. I tell this story to parents and educators who seek to force kids with autism to be something they are not, who pressure them into compliance or try to coerce them to be part of this world before they are ready. My experience with my son Neal — who I adopted from a Russian orphanage at age two and who was diagnosed with autism a year later — has taught me that we must yield to slow yet natural progress: caterpillar to chrysalis to beautiful creatures that can soar on their own. But it took me a while to learn this for myself.
I had a significant “a-ha!” moment when Neal was seven years old. I had been taking Neal out into the community quite a bit, trying desperately hard to have a normal life and fit in. Anything that Neal was interested in, I pursued. Because Neal loved butterflies, I was overjoyed to hear about a butterfly exhibit that was coming to the Los Angeles Natural History Museum. It sounded extraordinary, a “Pavilion of Wings.” The brochure read, “Stroll through a beautifully landscaped exhibit, see Monarch butterflies, giant swallow tail butterflies and more.” I couldn’t wait.
I prepared Neal with butterfly books and manuals. We acted out the life cycle of a butterfly. We crawled like caterpillars, munched on leaves and rolled ourselves into a cocoon and wait, wait, waited, until we developed wings. Then we flew around our house in a rainbow of laughter. I had often used this kind of creative play in my career as an acting coach for children. Being able to use these techniques with my own boy was even more rewarding. We had so much fun together.
Finally, the exhibit opens, and on that day I get Neal into the car effortlessly and we head downtown to the museum. Neal is a little reluctant to walk across the large parking lot, but once he nears the exhibit, his eyes widen with excitement.
We enter the Pavilion. Neal is in awe: hundreds of butterflies in all shapes and colors flick and flutter around us. Neal loves the butterflies. He loves them too much. When he sees these familiar, angel-like creatures, he wants to get close to them, to smell them, to touch them. He starts reaching out ecstatically to touch each butterfly. Like King Kong snatching airplanes from atop the Empire State Building, Neal grabs for butterflies.
“He’s killing the butterflies!” shouts a little boy.
“Butterfly killer!” screams a tiny girl.
Now all the kids and adults are yelling, “Stop him! Get him! He’s killing the butterflies!!!
“Murderer!”
This terrifies Neal. He grabs a plant and pulls it out of its pot. He knocks over other pots. The butterflies are flapping wildly. A security guard swoops in.
“I am so sorry,” I keep saying. “I am so sorry. He has autism. He loves butterflies. He didn’t mean to harm them.”
“Get that kid out of here!” someone shouts, loudly enough to be heard over the others who are still screaming at Neal.
But Neal doesn’t want to leave. He is actually quite amused by the commotion he’s causing, and I can’t get him out of the exhibit. Finally, I see some plastic, made-to-look-real butterflies on the gift shop counter. I rush to the front of the line. People glare at me for cutting in. I beg to buy one of the pretend Monarchs. I can’t wait for change, so I place a $10.00 bill on the counter, grab a fake butterfly, and race back to Neal. I use this insect amulet to coax Neal out of the Pavilion, through the long parking lot and back to the car.
Sitting in the car, Neal and I stare blankly out the front window. I look at Neal. I see the puzzled look in his eyes give way to sadness. I start to cry. Neal stares back at me. He gets teary-eyed. He’s ashamed of what happened. We look long at each other. The tears give way to smiles. The smiles become laughter. It’s one of those situations in which everything is so terrible, that it’s ultimately absurd.
But that night I pray. “Dear God, I need help. We need help. It’s just not working.”
I fell apart that day. I surrendered to the fact that our lives are just going to be a bit different from the norm. “Abbynormal,” I like to say. From that day on I became 100 percent committed to keeping Neal at home and bringing in creative folks — actors, musicians, writers — to join his world, until he was ready to be in ours. Gradually, inch by inch, Neal did, indeed, emerge from his cocoon as a glorious butterfly — but on his own schedule, not mine. Among many other things, now Neal can sit patiently and watch a butterfly float by without any need to “possess it.”
Through writing my memoir, Now I See the Moon, I was able realize that some things in life, as in nature, cannot be rushed. Luckily, the right teachers, the right programs, the right books and the right methodologies always appeared just when I needed them most. Neal will always be my guide as to what he is ready for and when he’s ready for it. A caterpillar knows best when he is ready to break out of the cocoon and emerge as the graceful butterfly he was always capable of becoming.
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Appeal for witnesses after assault leaves man temporarily blinded
The Autism News | English
By Matthew Gooding | Royston Crow 24
AN autistic man was left partially blinded after an assault in Royston.
Police are appealing for witnesses to the incident, which left the 33-year old victim requiring medical attention.
The attack happened on Thursday June 24 at about 1am in Normans Lane, off Upper Kings Street near the Old Bull Inn. The victim approached another man to talk to him, and this man then assaulted the 33 year old before making off in the direction of Briary Lane.
PC Steve Penhall, investigating, said: “The victim, who suffers with autism, suffered temporary loss of vision to his left eye. This was an unprovoked attack as the victim meant no harm when he tried to engage the man in conversation.
“We believe the suspect maybe local and I would like to appeal to anyone who saw what happened or has any information about the assault to contact us,” he said.
The offender is described as a white man aged in his late teens – early 20s. He was about 5 feet, 9 inches tall, had blonde spiky hair, and was wearing light blue jeans and a pale blue top.
Anyone with information should call Hertfordshire Police on 0845 3300 222 quoting crime reference number G4/10/475. Alternatively phone Crimestoppers anonymously on 0800 555111. You do not have to give your name and you could be entitled to a cash reward.
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Otis Horse Therapy Program Helps Its First Students
The Autism News | English
By Sarah Komuniecki | WABI
Earlier this year we told you about an Otis woman who was starting a horse therapy program, to help teach children with autism and special needs.
Last week the non-profit Springy Pond Farm kicked off its “Ride to Read” program, and welcomed its first official students– including seven-year-old Zach.
Today was seven-year-old Zach’s second visit to Springy Pond Farm in Otis. He has autism, and medical needs that at one time almost claimed his life. But now, his mother, Michelle Neal, says he’s doing well.
“He talked about it all week. He loved it. He loves Jen too,” Neal says.
Jennifer Cammack has been Zach’s occupational therapist for the past two years. Now she’s working with him in the “Ride to Read” program, using specially trained horses on her farm to help teach everything from life skills to letters and numbers.
“It’s a ‘z.’ What sound does ‘z’ make? ‘zzzz.’ Very good!”
“We’re using the horse and the movement of the horse to facilitate attention and to stimulate a lot of language and learning in his brain,” Cammack says. “One of Zach’s greatest challenges is staying on task and attentive to something. Today’s session was three times as long as last week’s session so he’s already showing progress, which is really exciting.”
Zach’s mom says the farm is about an hour-and-a half drive from her home, but she would drive even farther for a program that helps her son this much.
“You can see how calm he is compared to before. He was all over the place,” Neal says. “Jen is awesome. We feel very blessed to have her as his OT, and this just feels, watching, it’s like a miracle.”
Cammack says community support has helped the farm achieve its early success. Now the non-profit is actively fundraising to keep growing, and help more students attend when insurance doesn’t cover the entire cost.
She says she couldn’t be happier to see Springy Pond Farm up and running.
“Oh,” she says, “it’s my dream come true.”
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Taekwondo helped girl shed shyness, find confidence
The Autism News | English
Jacquelyn Anderson‘s mom, Kristy, tried several different activities to help her daughter socially, before finding tae kwon do. Now 8 years old, Jacquelyn is a black belt and more outgoing and confident, says her mom.
By Nancy Churnin | The Dallas Morning News
The Karate Kid, the Jaden Smith- Jackie Chan remake of the 1984 hit film of the same name, is the story of how martial arts can turn a young boy’s life around, building his respect for himself and others as it prepares him to face the bullies that torment him.
Kristy Anderson of Flower Mound wants everyone to know that martial arts can turn a young girl’s life around, too.
Anderson’s daughter, Jacquelyn, displayed signs of autism at 18 months. At age 3, her diagnosis was sensory integrated disorder; she could not speak and was so sensitive to sounds that she would go to school wearing earplugs.
Kids at school teased and bullied her. At one point, a shove at the playground led to a fractured shoulder blade. Anderson tried everything she could think of to help her daughter fit in, including signing her up for team sports and music lessons. But the breakthrough came when Jacquelyn, then 4, joined a friend in karate class.
Bill Mischke, chief instructor and owner of Flower Mound Taekwondo, remembers that Jacquelyn seemed “a little bit shy,” when she first walked into the studio.
At the same time, he notes, “She seemed to enjoy it and picked things up quicker than I thought she would.”
It didn’t bother him that she was a girl. About half his students are girls, and they tend to outperform the boys, especially in the early years, when they are in the same competition group, he said.
“I had a father of a young girl who once asked, ‘Is my daughter going to have to be in this competition with these boys?’ and my answer was, ‘They better hope not.’ “
Nor was he concerned about any of Jacquelyn’s special needs. He says that often kids on the autism spectrum flourish in his classes because he offers a structured environment with a lot of repetition. The bottom line, he says, is that while most team sports are in what he calls “the business of elimination” – weeding kids out – anyone who is willing to work hard with him for a minimum of 21/2 years can earn a black belt. And Jacquelyn, he says, has worked hard.
“She’s always paid attention and she’s always practiced and been a good student,” he says.
Jacquelyn, now 8, has not only become Mischke’s youngest black belt, she has become verbal and friendlier and more confident, according to her mother. In addition to passing increasingly difficult physical tests to earn that belt, Jacquelyn had to complete a 500-word essay. She worked four months on it. The theme that threads through it is the importance of perseverance.
“When I first started tae kwon do it wasn’t so easy,” Jacquelyn writes. “Because if it was easy, everyone would be a black belt. Tae kwon do gets harder and harder as you go and sometimes you just don’t make it. I did not give up even though I wanted to a couple of times when it got really, really hard. But I didn’t and I just kept at it. Just like in Star Wars Yoda says, ‘DO OR DO NOT. THERE IS NO TRY.’ Getting my black belt will be the accomplishment of my life.”
Tae kwon do has also proved a fun way to help Jacquelyn get and stay fit, her mother says. The sport requires high-intensity aerobic exercise, strengthening and conditioning through punching and kicking moves.
Jacquelyn was on a demo team that performed before a screening of the new Karate Kid movie last month. The kid-led group demonstrated skills with nunchucks and wooden bowstaffs, breaking boards and doing a skit that shows little black-belt kids winning against larger and older bullies.
Jacquelyn says the message of the movie echoes what she learned in class: “Nobody’s perfect and everyone messes up some time or another,” she says.
She wasn’t bothered by the fact that there weren’t any girls doing tae kwon do in the movie. Actually, she didn’t realize that there weren’t any girls doing tae kwon do, her mother says.
“To be honest, she thought because of his long hair that the little boy was a girl.”
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Mum Suzanne tells of setting up school for autistic son
The Autism News | English
Freddie Buckner’s mother set up a school for him
By Jenny Minard | BBC Berkshire
Imagine living with a child with autism. And then imagine having to fight tooth and nail to get him a school place.
That’s what Suzanne Buckner had to do after her nine-year-old son Freddie was excluded from school.
But she didn’t give up on his education; instead she set up a school and employed a specialist teacher to help him.
“Freddie went to private school,” she said.
“They would do charming things to him like put him in the middle of a circle of friends so they could tell him why they disliked him.
“It was a struggle to try to get him into a car after he put his foot through an industrial washing machine, or through pained glass.
“He just began to inherently dislike school and everything it represented.
“We then ended up at a local primary school, which we selected because it had a Christian-based ethos.
“Yet again, within a few weeks, Freddie was on a table by himself, then we started getting phone calls, then he was permanently excluded after 12 o’clock.”
So Suzanne set up the facility in South Street, Reading, in October 2008. But Freddie is still the only pupil in the school despite it being Ofsted registered and inspected.
Complex autism
Suzanne says that other children with complex autism could be taught there, saving the Local Education Authority hundreds of thousands of pounds because they wouldn’t have to send them out of the area.
Freddie is hyper intelligent. His IQ is in the top 4% in country for his age but he is in the lowest 4% for short term memory.
This means he gets very cross very quickly and when frustrated he is unable to express himself except through physical means.
Although Freddie’s school is an independent school, the pupil’s costs are met by the family’s Wokingham LEA which pays £54,000 annually.
That covers the running costs in the building which Suzanne herself already owned.
The school in the centre of Reading has two classrooms, each with several desks, posters on walls – all the ‘normal’ school stuff you’d expect. It has a playground outside with hopscotch area and football goals.
Suzanne explained that a simple test might help all children who have the symptoms Freddie went through.
“Typically these children end up in secondary school, under performing, under achieving,” she said.
“40% of children presented to secondary school can’t read or write which means they can’t access education.
“There are some very cheap simple tests like hearing, eye and dyslexia testing which would cost us as tax payers £500 per child.
“It would very quickly access what is going on with a child. An awful lot of children get labelled with autism and ASD and it’s almost because it’s an easier diagnosis to give than some of the perhaps more complex diagnosis that we deal with.
Soul destroying
She described what was like seeing her son go through expulsion.
“It’s absolutely soul destroying and it takes a toll on the family and the carers that have to be involved with a child like this.
“You’ve got to cope with their behaviours – my son has threatened me with knives and with screwdrivers.
“He can be highly unpredictable, he is highly complex. That is hard enough in itself without having to fight people that we pay to be in positions, supposedly to help, when they don’t necessarily.
“There are an awful lot of political agendas going on and they don’t help the children, they don’t help the family.
Now she says he is doing really well at her school.
“He is getting a wonderful education. I can’t describe to you the day that he wrote my husband and I a letter.
“He is now out performing mainstream school children at his age in many subjects although he is profoundly dyslexic.”
Parents’ preference
Councillor Mark Ralph is the lead councillor for education and children’s services in Reading.
He said: “It’s relatively new and we respond to parents’ preferences regarding schools and providing that in the best interest of the child and to date we haven’t had any parents wanting to send their children to Freddie’s.”
Councillor Rob Stanton is the executive member for children’s services in Wokingham.
He said: “I do believe we are and again this is worked out by educational psychiatrists with the parents. Parents have a preference here.
“There is another issue with Wokingham in that we do have Abingdon School within our area.
“That is an outstanding school and offers superb facilities for some of these young people. So we do have very good facilities and there are many others too in the areas around, Reading, Maidenhead etc.
“We are very open-minded about this but no-one has actually asked for that particular school for that child.”
Have your say
Suzanne Buckner runs the school in Reading
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Autistic Teenager Finds Voice Through Social Networking
The Autism News | English
By Gabrielle Moore | Global Shift
Carly Fleischmann — a young woman whose autism left her mute — has found her voice through the use of the Internet.
Fleischmann is able to type her thoughts into a computer, and now communicates with thousands of people through her Twitter and Facebook pages. She has found a way to use the social networking phenomenon, along with e-mail, to communicate with people all over the world — many of whom are curious about autism or have a friend or family member with the disorder. Carly says she does what she can to teach others about autism and what it is like for her — a message that she says comes “straight from the horse’s mouth.”
Recently, Carly spoke at an autism event to introduce one of her heroes, Temple Grandin. Similarly to Carly, Grandin was diagnosed with autism at a young age, and was unable to communicate. When she was diagnosed, so little was known about autism and its causes that the doctor told her mother it was the fault of poor parenting. However, Grandin’s family helped her grow and learn through therapy, and eventually she became a well-recognized and respected animal scientist. Carly was able to meet Grandin and introduce her at an event by typing out her speech for the audience.
Carly has made efforts to raise awareness about autism, and has found a way to talk to friends, family and the entire world by reaching out and discovering how to make a positive situation out of her inability to speak. You can learn more about Carly and ask her questions about autism on her website.
Source: http://www.globalshift.org/2010/07/06/autistic-teenager-finds-voice-through-social-networking
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